CAMERA2 - combination antibiotic therapy for methicillin-resistant Staphylococcus aureus infection: Study protocol for a randomised controlled trial

SYC Tong; J Nelson; DL Paterson; VG Fowler; BP Howden; AC Cheng; M Chatfield; J Lipman; S Van Hal; M O'Sullivan; JO Robinson; D Yahav; D Lye; JS Davis

Journal article

CAMERA2 - combination antibiotic therapy for methicillin-resistant Staphylococcus aureus infection: Study protocol for a randomised controlled trial

SYC Tong, J Nelson, DL Paterson, VG Fowler, BP Howden, AC Cheng, M Chatfield, J Lipman, S Van Hal, M O'Sullivan, JO Robinson, D Yahav, D Lye, JS Davis

Trials | Published : 2016

DOI: 10.1186/S13063-016-1295-3

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Abstract

Background: Methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia is a serious infection resulting in 20-50 % 90-day mortality. The limitations of vancomycin, the current standard therapy for MRSA, make treatment difficult. The only other approved drug for treatment of MRSA bacteraemia, daptomycin, has not been shown to be superior to vancomycin. Surprisingly, there has been consistent in-vitro and in-vivo laboratory data demonstrating synergy between vancomycin or daptomycin and an anti-staphylococcal β-lactam antibiotic. There is also growing clinical data to support such combinations, including a recent pilot randomised controlled trial (RCT) that demonstrated a trend towards a r..

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University of Melbourne Researchers

Ben Howden Author

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Grants

Awarded by National Medical Research Council

Funding Acknowledgements

The study is funded by an Australian National Health and Medical Research Council Project grant (1078930), a Singapore National Medical Research Council Clinical Trial Grant (CTGIITL14nov001), and a Ramaciotti Foundation Establishment Grant (ES2014/079).